ourpana.blogg.se - Free download glucose structure

Structural comparison of the uniporter GLUT1 with its bacterial homologue XylE, a proton-coupled xylose symporter, allows examination of the transport mechanisms of both passive facilitators and active transporters.ġ] State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China. Structure-based analysis of these mutations provides an insight into the alternating access mechanism of GLUT1 and other members of the sugar porter subfamily. This structure allows accurate mapping and potential mechanistic interpretation of disease-associated mutations in GLUT1. The full-length protein, which has a canonical major facilitator superfamily fold, is captured in an inward-open conformation. Here we report the crystal structure of human GLUT1 at 3.2 Å resolution. Despite decades of investigation, the structure of GLUT1 remains unknown. Dysfunctional mutations may lead to GLUT1 deficiency syndrome, whereas overexpression of GLUT1 is a prognostic indicator for cancer. The glucose transporter GLUT1 catalyses facilitative diffusion of glucose into erythrocytes and is responsible for glucose supply to the brain and other organs. Diversity, Equity, Inclusion, and Access.Citation, Usage, Privacy Policies, Logo.Biologically Interesting Molecule Reference Dictionary (BIRD).A copy of the license is included in the section entitled GNU Free Documentation License. The alpha-D-glucose structure data file can be imported to most of the cheminformatics software systems and applications.

Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. The structure data file (SDF/MOL File) of alpha-D-glucose is available for download in the SDF page of alpha-D-glucose, which provides the information about the atoms, bonds, connectivity and coordinates of alpha-D-glucose. CC BY-SA 3.0 Creative Commons Attribution-Share Alike 3.0 true true

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